Summary
I am currently a senior research associate at Department of Pediatrics of Duke University. My research interest is in neurodevelopment disorders with a focus on Autism. I have generated two different Shank3 gene knockout mouse models for Autism study and led a research team to characterize these mouse models. One of these mouse models has been purchased by Roche for drug development for Autism. In addition, my study has revealed multiple intragenic promoters and transcriptional complexity of Shank3 gene, providing a molecular framework to interpret the behavioral heterogeneity of Autism. Based on these unique knowledge, I have generated the first Shank3 gene complete knockout mouse model for Phenlan-McDermid syndrome and Autism by employing a two-step gene targeting strategy and Cre-loxp system.
Education
• Ph.D. in Biochemistry and Molecular Biology (Jun 19, 2008)
Shanghai Medical College, Fudan University, Shanghai, China
• M.S. in Pharmacology (Jun 4, 2003)
Dalian Medical University, Dalian, China
• B.S. in Clinic Medicine (Jul 4, ... |