SUMMARY
Established protein chemist/structural biologist with 10+ years of academic and industry experiences in protein chemistry, structural biology, molecular modeling and structure based drug design.
Skills:
Protein Chemistry: Experience and in depth knowledge in protein expression, purification, and characterization using FPLC, HPLC, gel filtration, gel electrophoresis, reverse phase/ion exchange chromatography and other protein chemistry techniques.
Rational drug design and molecular modeling: Project design and execution. Target based ligand design. structure based ligand optimization, Molecular modeling, Strong understanding on the fundamental concepts of drug development. Skills in using molecular modeling packages such as Schrodinger, Discovery Studio and MOE.
Structural Biology: Crystallization screen and optimization, structural study of target protein and target protein/ligand complex. Data collection, phasing, map interpretation and structure refinement. Windows/Linux and OSX operating systems. Crystallographic laboratory management , s... |