Our interdisciplinary research groups work on complex regulations of actin remodeling during signal transduction under physiological and pathological conditions. We study molecular mechanisms by which biomolecular phase separation finetunes physical-chemical properties of the macromolecular complex to reorganize actin polymerization by tuning the biochemical activities in the membrane-associated membrane-less organelles. We also focus on the mechanisms of mechanosensing and mechanotransduction, by which cell wall (CW) – plasma membrane (PM) – actin cytoskeleton (AC) continuum regulates molecular dynamics and functions of the integrated biomolecules through tunning their molecular condensation and thereby modulates cellular signal transductions.
